Publications

We post our published works on this page. You can also find additional information about our research activities via the links below.

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Selected

Prediction of mechanistic subtypes of Parkinson’s using patient-derived stem cell models

Karishma D’Sa, James R. Evans, Gurvir S. Virdi, Giulia Vecchi, Alexander Adam, ..., Craig Leighton, Mathew H. Horrocks, Dilan Athauda, Minee L. Choi, Sonia Gandhi

Nature Machine Intelligence · 10 Aug 2023 · doi:10.1038/s42256-023-00702-9

AI Parkinson's hiPSC Corresponding author

Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity

Minee L. Choi, Alexandre Chappard, Bhanu P. Singh, Catherine Maclachlan, Margarida Rodrigues, ..., Lucy Collinson, David Klenerman, Andrey Y. Abramov, Mathew H. Horrocks, Sonia Gandhi

Nature Neuroscience · 30 Aug 2022 · doi:10.1038/s41593-022-01140-3

Synucleinopathy Protein aggregation Parkinson's Mitochondria hiPSC 1st Author

Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson’s disease pathogenesis

Craig D. Hughes, Minee L. Choi, Mina Ryten, Lee Hopkins, Anna Drews, ..., Margarida Rodrigues, Sarah A. Gagliano, Sonia Gandhi, Clare Bryant, David Klenerman

Acta Neuropathologica · 17 Sep 2018 · doi:10.1007/s00401-018-1907-y

Parkinson's Alpha-Synuclein 1st Author

All

AI hiPSC Parkinson's Alzheimer's Mitochondria Protein aggregation Cell death Ferroptosis Inflammation Synucleinopathy Fabry disease Huntington's Hippocampus Learning Memory Neurogenesis 1st Author Corresponding Author

2023

Prediction of mechanistic subtypes of Parkinson’s using patient-derived stem cell models

Karishma D’Sa, James R. Evans, Gurvir S. Virdi, Giulia Vecchi, Alexander Adam, ..., Craig Leighton, Mathew H. Horrocks, Dilan Athauda, Minee L. Choi, Sonia Gandhi

Nature Machine Intelligence · 10 Aug 2023 · doi:10.1038/s42256-023-00702-9

AI Parkinson's hiPSC Corresponding author

2022

Protein aggregation and calcium dysregulation are hallmarks of familial Parkinson’s disease in midbrain dopaminergic neurons

Gurvir S. Virdi, Minee L. Choi, James R. Evans, Zhi Yao, Dilan Athauda, ..., Tilo Kunath, Mathew H. Horrocks, Andrey Y. Abramov, Rickie Patani, Sonia Gandhi

npj Parkinson's Disease · 24 Nov 2022 · doi:10.1038/s41531-022-00423-7

Protein aggregation Parkinson's hiPSC

Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity

Minee L. Choi, Alexandre Chappard, Bhanu P. Singh, Catherine Maclachlan, Margarida Rodrigues, ..., Lucy Collinson, David Klenerman, Andrey Y. Abramov, Mathew H. Horrocks, Sonia Gandhi

Nature Neuroscience · 30 Aug 2022 · doi:10.1038/s41593-022-01140-3

Synucleinopathy Protein aggregation Parkinson's Mitochondria hiPSC 1st Author

The Impact of Type 2 Diabetes in Parkinson's Disease

Dilan Athauda, James Evans, Anna Wernick, Gurvir Virdi, Minee L. Choi, ..., Khalida Ismail, Huw Morris, Donald Grosset, Thomas Foltynie, Sonia Gandhi

Movement Disorders · 14 Jun 2022 · doi:10.1002/mds.29122

Parkinson's

2020

Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation

Plamena R. Angelova, Minee L. Choi, Alexey V. Berezhnov, Mathew H. Horrocks, Craig D. Hughes, ..., Sergiy Sylantyev, Evgeny V. Pavlov, David Klenerman, Andrey Y. Abramov, Sonia Gandhi

Cell Death & Differentiation · 27 Apr 2020 · doi:10.1038/s41418-020-0542-z

Synucleinopathy Protein aggregation Parkinson's Ferroptosis 1st Author

Beta amyloid aggregates induce sensitised TLR4 signalling causing long-term potentiation deficit and rat neuronal cell death

Craig Hughes, Minee L. Choi, Jee-Hyun Yi, Seung-Chan Kim, Anna Drews, Peter St. George-Hyslop, Clare Bryant, Sonia Gandhi, Kwangwook Cho, David Klenerman

Communications Biology · 18 Feb 2020 · doi:10.1038/s42003-020-0792-9

Inflammation Alzheimer's Protein aggregation hiPSC

Tracking Oligomerization of Alpha-Synuclein Demonstrates Pivotal Role of Mitochondria in Seeding

Minee L. Choi, Mathew H. Horrocks, Margarida Rodrigues, Suman De, Laura Tosatto, Weilia Zhang, Gurvir Virdi, David Klenerman, Andrey Y. Abramov, Sonia Gandhi

Biophysical Journal · 01 Feb 2020 · doi:10.1016/j.bpj.2019.11.1289

Alpha-Synuclein Mitochondria 1st Author

2018

Nanoscopic Characterisation of Individual Endogenous Protein Aggregates in Human Neuronal Cells

Daniel R. Whiten, Yukun Zuo, Laura Calo, Minee‐Liane Choi, Suman De, ..., Christopher M. Dobson, Sonia Gandhi, Maria‐Grazia Spillantini, David Klenerman, Mathew H. Horrocks

ChemBioChem · 04 Oct 2018 · doi:10.1002/cbic.201800209

Protein aggregation hiPSC

Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson’s disease pathogenesis

Craig D. Hughes, Minee L. Choi, Mina Ryten, Lee Hopkins, Anna Drews, ..., Margarida Rodrigues, Sarah A. Gagliano, Sonia Gandhi, Clare Bryant, David Klenerman

Acta Neuropathologica · 17 Sep 2018 · doi:10.1007/s00401-018-1907-y

Parkinson's Alpha-Synuclein 1st Author

Crucial role of protein oligomerization in the pathogenesis of Alzheimer's and Parkinson's diseases

Minee L. Choi, Sonia Gandhi

The FEBS Journal · 21 Aug 2018 · doi:10.1111/febs.14587

Parkinson's Alzheimer's hiPSC 1st Author

α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease

Marthe H. R. Ludtmann, Plamena R. Angelova, Mathew H. Horrocks, Minee L. Choi, Margarida Rodrigues, ..., Morana Jaganjac, Evgeny V. Pavlov, David Klenerman, Andrey Y. Abramov, Sonia Gandhi

Nature Communications · 12 Jun 2018 · doi:10.1038/s41467-018-04422-2

Parkinson's Alpha-Synuclein hiPSC

Overproduction of reactive oxygen species is the primary pathological event related to neuronal cell death in iPSC derived neurons from patients with familial Parkinson's disease

Minee L Choi, Ruta Meleckyte, Daniel Little, Andrey Y Abramov, Rickie Patani, Sonia Gandhi

Free Radical Biology and Medicine · 01 May 2018 · doi:10.1016/j.freeradbiomed.2018.04.532

Parkinson's Cell death iPSC 1st Author

Alpha-synuclein induces ferroptosis through generation of lipid peroxidation and calcium deregulation

Plamena R. Angelova, Minee-Liane Choi, Mathew H. Horrocks, David Klenerman, Sonia Gandhi, Andrey Y. Abramov

Free Radical Biology and Medicine · 01 May 2018 · doi:10.1016/j.freeradbiomed.2018.04.137

Alpha-Synuclein Ferroptosis

2017

Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species

Marija Iljina, Liu Hong, Mathew H. Horrocks, Marthe H. Ludtmann, Minee L. Choi, ..., Michele Vendruscolo, Tuomas P. J. Knowles, Christopher M. Dobson, Erwin De Genst, David Klenerman

BMC Biology · 03 Jul 2017 · doi:10.1186/s12915-017-0390-6

Alpha-Synuclein

Progressive Motor Neuron Pathology and the Role of Astrocytes in a Human Stem Cell Model of VCP-Related ALS

Claire E. Hall, Zhi Yao, Minee Choi, Giulia E. Tyzack, Andrea Serio, ..., Christopher R. Sibley, Andras Lakatos, Jernej Ule, Sonia Gandhi, Rickie Patani

Cell Reports · 01 May 2017 · doi:10.1016/j.celrep.2017.05.024

Parkinson's

Direct Modulation of the Mitochondrial Permeability Transition Pore by Oligomeric Alpha-Synuclein Causes Toxicity in PD

Marthe Ludtmann, Plamena Angelova, Minee-Liane Choi, Mathew Horrocks, Artyom Baev, ..., Paul Gissen, Evgeny Pavlov, David Klenerman, Andrey Abramov, Sonia Gandhi

Biophysical Journal · 01 Feb 2017 · doi:10.1016/j.bpj.2016.11.2351

Parkinson's Mitochondria hiPSC

2016

Arachidonic acid mediates the formation of abundant alpha-helical multimers of alpha-synuclein

Marija Iljina, Laura Tosatto, Minee L. Choi, Jason C. Sang, Yu Ye, Craig D. Hughes, Clare E. Bryant, Sonia Gandhi, David Klenerman

Scientific Reports · 27 Sep 2016 · doi:10.1038/srep33928

Parkinson's Alpha-Synuclein

Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading

Marija Iljina, Gonzalo A. Garcia, Mathew H. Horrocks, Laura Tosatto, Minee L. Choi, ..., Nicholas W. Wood, Nunilo Cremades, Christopher M. Dobson, Tuomas P. J. Knowles, David Klenerman

Proceedings of the National Academy of Sciences · 16 Feb 2016 · doi:10.1073/pnas.1524128113

Parkinson's Alpha-Synuclein