BRAIN RePAIR & ORGANØID 1NTEL by Minee Choi

Publications

We post our published works on this page. You can also find additional information about our research activities via the links below.

Selected

Prediction of mechanistic subtypes of Parkinson’s using patient-derived stem cell models
Prediction of mechanistic subtypes of Parkinson’s using patient-derived stem cell models
Karishma D’Sa, James R. Evans, Gurvir S. Virdi, Giulia Vecchi, Alexander Adam, ..., Craig Leighton, Mathew H. Horrocks, Dilan Athauda, Minee L. Choi, Sonia Gandhi
Nature Machine Intelligence   ·   10 Aug 2023   ·   doi:10.1038/s42256-023-00702-9
Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity
Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity
Minee L. Choi, Alexandre Chappard, Bhanu P. Singh, Catherine Maclachlan, Margarida Rodrigues, ..., Lucy Collinson, David Klenerman, Andrey Y. Abramov, Mathew H. Horrocks, Sonia Gandhi
Nature Neuroscience   ·   30 Aug 2022   ·   doi:10.1038/s41593-022-01140-3
Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson’s disease pathogenesis
Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson’s disease pathogenesis
Craig D. Hughes, Minee L. Choi, Mina Ryten, Lee Hopkins, Anna Drews, ..., Margarida Rodrigues, Sarah A. Gagliano, Sonia Gandhi, Clare Bryant, David Klenerman
Acta Neuropathologica   ·   17 Sep 2018   ·   doi:10.1007/s00401-018-1907-y

All

2024

The diversity of<i>SNCA</i>transcripts in neurons, and its impact on antisense oligonucleotide therapeutics
The diversity ofSNCAtranscripts in neurons, and its impact on antisense oligonucleotide therapeutics
James R. Evans, Emil K. Gustavsson, Ivan Doykov, David Murphy, Gurvir S. Virdi, ..., Michele Vendruscolo, Kevin Mills, Wendy Heywood, Mina Ryten, Sonia Gandhi
Cold Spring Harbor Laboratory   ·   31 May 2024   ·   doi:10.1101/2024.05.30.596437
GLP1 receptor agonism ameliorates Parkinson’s disease through modulation of neuronal insulin signalling and glial suppression
GLP1 receptor agonism ameliorates Parkinson’s disease through modulation of neuronal insulin signalling and glial suppression
Dilan Athauda, James R Evans, Laura Mahoney-Sanchez, Gurvir S Virdi, Patricia Lopez-Garcia, ..., Mina Ryten, Mathew H. Horrocks, Nigel Greig, Thomas Foltynie, Sonia Gandhi
Cold Spring Harbor Laboratory   ·   28 Feb 2024   ·   doi:10.1101/2024.02.28.582460
Alpha-synuclein aggregates trigger anti-viral immune pathways and RNA editing in human astrocytes
Alpha-synuclein aggregates trigger anti-viral immune pathways and RNA editing in human astrocytes
Karishma D’Sa, Minee L. Choi, Aaron Z. Wagen, Núria Setó-Salvia, Olga Kopach, ..., Rickie Patani, Clare Bryant, David A. Klenerman, Sonia Gandhi, Mina Ryten
Cold Spring Harbor Laboratory   ·   28 Feb 2024   ·   doi:10.1101/2024.02.26.582055

2023

Prediction of mechanistic subtypes of Parkinson’s using patient-derived stem cell models
Prediction of mechanistic subtypes of Parkinson’s using patient-derived stem cell models
Karishma D’Sa, James R. Evans, Gurvir S. Virdi, Giulia Vecchi, Alexander Adam, ..., Craig Leighton, Mathew H. Horrocks, Dilan Athauda, Minee L. Choi, Sonia Gandhi
Nature Machine Intelligence   ·   10 Aug 2023   ·   doi:10.1038/s42256-023-00702-9

2022

Protein aggregation and calcium dysregulation are hallmarks of familial Parkinson’s disease in midbrain dopaminergic neurons
Protein aggregation and calcium dysregulation are hallmarks of familial Parkinson’s disease in midbrain dopaminergic neurons
Gurvir S. Virdi, Minee L. Choi, James R. Evans, Zhi Yao, Dilan Athauda, ..., Tilo Kunath, Mathew H. Horrocks, Andrey Y. Abramov, Rickie Patani, Sonia Gandhi
npj Parkinson's Disease   ·   24 Nov 2022   ·   doi:10.1038/s41531-022-00423-7
Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity
Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity
Minee L. Choi, Alexandre Chappard, Bhanu P. Singh, Catherine Maclachlan, Margarida Rodrigues, ..., Lucy Collinson, David Klenerman, Andrey Y. Abramov, Mathew H. Horrocks, Sonia Gandhi
Nature Neuroscience   ·   30 Aug 2022   ·   doi:10.1038/s41593-022-01140-3
The Impact of Type 2 Diabetes in Parkinson's Disease
The Impact of Type 2 Diabetes in Parkinson's Disease
Dilan Athauda, James Evans, Anna Wernick, Gurvir Virdi, Minee L. Choi, ..., Khalida Ismail, Huw Morris, Donald Grosset, Thomas Foltynie, Sonia Gandhi
Movement Disorders   ·   14 Jun 2022   ·   doi:10.1002/mds.29122

2020

Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation
Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation
Plamena R. Angelova, Minee L. Choi, Alexey V. Berezhnov, Mathew H. Horrocks, Craig D. Hughes, ..., Sergiy Sylantyev, Evgeny V. Pavlov, David Klenerman, Andrey Y. Abramov, Sonia Gandhi
Cell Death & Differentiation   ·   27 Apr 2020   ·   doi:10.1038/s41418-020-0542-z
Beta amyloid aggregates induce sensitised TLR4 signalling causing long-term potentiation deficit and rat neuronal cell death
Beta amyloid aggregates induce sensitised TLR4 signalling causing long-term potentiation deficit and rat neuronal cell death
Craig Hughes, Minee L. Choi, Jee-Hyun Yi, Seung-Chan Kim, Anna Drews, Peter St. George-Hyslop, Clare Bryant, Sonia Gandhi, Kwangwook Cho, David Klenerman
Communications Biology   ·   18 Feb 2020   ·   doi:10.1038/s42003-020-0792-9
Tracking Oligomerization of Alpha-Synuclein Demonstrates Pivotal Role of Mitochondria in Seeding
Tracking Oligomerization of Alpha-Synuclein Demonstrates Pivotal Role of Mitochondria in Seeding
Minee L. Choi, Mathew H. Horrocks, Margarida Rodrigues, Suman De, Laura Tosatto, Weilia Zhang, Gurvir Virdi, David Klenerman, Andrey Y. Abramov, Sonia Gandhi
Biophysical Journal   ·   01 Feb 2020   ·   doi:10.1016/j.bpj.2019.11.1289

2018

Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson’s disease pathogenesis
Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson’s disease pathogenesis
Craig D. Hughes, Minee L. Choi, Mina Ryten, Lee Hopkins, Anna Drews, ..., Margarida Rodrigues, Sarah A. Gagliano, Sonia Gandhi, Clare Bryant, David Klenerman
Acta Neuropathologica   ·   17 Sep 2018   ·   doi:10.1007/s00401-018-1907-y
Nanoscopic Characterisation of Individual Endogenous Protein Aggregates in Human Neuronal Cells
Nanoscopic Characterisation of Individual Endogenous Protein Aggregates in Human Neuronal Cells
Daniel R. Whiten, Yukun Zuo, Laura Calo, Minee‐Liane Choi, Suman De, ..., Christopher M. Dobson, Sonia Gandhi, Maria‐Grazia Spillantini, David Klenerman, Mathew H. Horrocks
ChemBioChem   ·   11 Sep 2018   ·   doi:10.1002/cbic.201800209
α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease
α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease
Marthe H. R. Ludtmann, Plamena R. Angelova, Mathew H. Horrocks, Minee L. Choi, Margarida Rodrigues, ..., Morana Jaganjac, Evgeny V. Pavlov, David Klenerman, Andrey Y. Abramov, Sonia Gandhi
Nature Communications   ·   12 Jun 2018   ·   doi:10.1038/s41467-018-04422-2
Overproduction of reactive oxygen species is the primary pathological event related to neuronal cell death in iPSC derived neurons from patients with familial Parkinson's disease
Overproduction of reactive oxygen species is the primary pathological event related to neuronal cell death in iPSC derived neurons from patients with familial Parkinson's disease
Minee L Choi, Ruta Meleckyte, Daniel Little, Andrey Y Abramov, Rickie Patani, Sonia Gandhi
Free Radical Biology and Medicine   ·   01 May 2018   ·   doi:10.1016/j.freeradbiomed.2018.04.532
Alpha-synuclein induces ferroptosis through generation of lipid peroxidation and calcium deregulation
Alpha-synuclein induces ferroptosis through generation of lipid peroxidation and calcium deregulation
Plamena R. Angelova, Minee-Liane Choi, Mathew H. Horrocks, David Klenerman, Sonia Gandhi, Andrey Y. Abramov
Free Radical Biology and Medicine   ·   01 May 2018   ·   doi:10.1016/j.freeradbiomed.2018.04.137

2017

Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species
Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species
Marija Iljina, Liu Hong, Mathew H. Horrocks, Marthe H. Ludtmann, Minee L. Choi, ..., Michele Vendruscolo, Tuomas P. J. Knowles, Christopher M. Dobson, Erwin De Genst, David Klenerman
BMC Biology   ·   03 Jul 2017   ·   doi:10.1186/s12915-017-0390-6
Progressive Motor Neuron Pathology and the Role of Astrocytes in a Human Stem Cell Model of VCP-Related ALS
Progressive Motor Neuron Pathology and the Role of Astrocytes in a Human Stem Cell Model of VCP-Related ALS
Claire E. Hall, Zhi Yao, Minee Choi, Giulia E. Tyzack, Andrea Serio, ..., Christopher R. Sibley, Andras Lakatos, Jernej Ule, Sonia Gandhi, Rickie Patani
Cell Reports   ·   01 May 2017   ·   doi:10.1016/j.celrep.2017.05.024
Direct Modulation of the Mitochondrial Permeability Transition Pore by Oligomeric Alpha-Synuclein Causes Toxicity in PD
Direct Modulation of the Mitochondrial Permeability Transition Pore by Oligomeric Alpha-Synuclein Causes Toxicity in PD
Marthe Ludtmann, Plamena Angelova, Minee-Liane Choi, Mathew Horrocks, Artyom Baev, ..., Paul Gissen, Evgeny Pavlov, David Klenerman, Andrey Abramov, Sonia Gandhi
Biophysical Journal   ·   01 Feb 2017   ·   doi:10.1016/j.bpj.2016.11.2351

2016

Arachidonic acid mediates the formation of abundant alpha-helical multimers of alpha-synuclein
Arachidonic acid mediates the formation of abundant alpha-helical multimers of alpha-synuclein
Marija Iljina, Laura Tosatto, Minee L. Choi, Jason C. Sang, Yu Ye, Craig D. Hughes, Clare E. Bryant, Sonia Gandhi, David Klenerman
Scientific Reports   ·   27 Sep 2016   ·   doi:10.1038/srep33928
Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading
Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading
Marija Iljina, Gonzalo A. Garcia, Mathew H. Horrocks, Laura Tosatto, Minee L. Choi, ..., Nicholas W. Wood, Nunilo Cremades, Christopher M. Dobson, Tuomas P. J. Knowles, David Klenerman
Proceedings of the National Academy of Sciences   ·   16 Feb 2016   ·   doi:10.1073/pnas.1524128113
Strain Dependent Effects of Alpha-Synuclein Mutations on Mitochondrial Dysfunction
Strain Dependent Effects of Alpha-Synuclein Mutations on Mitochondrial Dysfunction
Minee L. Choi, Zhi Yao, Laura Tosatto, David Klenerman, Andrey Y. Abramov, Sonia Gandhi
Biophysical Journal   ·   01 Feb 2016   ·   doi:10.1016/j.bpj.2015.11.2522

2015

A simple assessment model to quantifying the dynamic hippocampal neurogenic process in the adult mammalian brain
A simple assessment model to quantifying the dynamic hippocampal neurogenic process in the adult mammalian brain
Minee L. Choi, Faye Begeti, Roger A. Barker, Namho Kim
Hippocampus   ·   03 Nov 2015   ·   doi:10.1002/hipo.22541
The Fabry disease-associated lipid Lyso-Gb3 enhances voltage-gated calcium currents in sensory neurons and causes pain
The Fabry disease-associated lipid Lyso-Gb3 enhances voltage-gated calcium currents in sensory neurons and causes pain
L. Choi, J. Vernon, O. Kopach, M.S. Minett, K. Mills, P.T. Clayton, T. Meert, J.N. Wood
Neuroscience Letters   ·   01 May 2015   ·   doi:10.1016/j.neulet.2015.01.084

2014

Dopaminergic manipulations and its effects on neurogenesis and motor function in a transgenic mouse model of Huntington's disease
Dopaminergic manipulations and its effects on neurogenesis and motor function in a transgenic mouse model of Huntington's disease
M.L. Choi, F. Begeti, J.H. Oh, S.Y. Lee, G.C. O'Keeffe, C.D. Clelland, P. Tyers, Z.H. Cho, Y.B. Kim, R.A. Barker
Neurobiology of Disease   ·   01 Jun 2014   ·   doi:10.1016/j.nbd.2014.02.004

2009

A Functional Role for Adult Hippocampal Neurogenesis in Spatial Pattern Separation
A Functional Role for Adult Hippocampal Neurogenesis in Spatial Pattern Separation
C. D. Clelland, M. Choi, C. Romberg, G. D. Clemenson, A. Fragniere, ..., S. Jessberger, L. M. Saksida, R. A. Barker, F. H. Gage, T. J. Bussey
Science   ·   10 Jul 2009   ·   doi:10.1126/science.1173215

2008

Vascular endothelial growth factor (VEGF) signaling regulates hippocampal neurons by elevation of intracellular calcium and activation of calcium/calmodulin protein kinase II and mammalian target of rapamycin
Vascular endothelial growth factor (VEGF) signaling regulates hippocampal neurons by elevation of intracellular calcium and activation of calcium/calmodulin protein kinase II and mammalian target of rapamycin
Byung Woo Kim, Minee Choi, Yong-Seok Kim, Hyungju Park, Hye-Ryeon Lee, ..., June-Seek Choi, Sunoh Kim, Hyewon Rhim, Bong-Kiun Kaang, Hyeon Son
Cellular Signalling   ·   01 Apr 2008   ·   doi:10.1016/j.cellsig.2007.12.009