Publications
We post our published works on this page. You can also find additional information about our research activities via the links below.
Selected
Prediction of mechanistic subtypes of Parkinson’s using patient-derived stem cell models
Nature Machine Intelligence
·
10 Aug 2023
·
doi:10.1038/s42256-023-00702-9
Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity
Nature Neuroscience
·
30 Aug 2022
·
doi:10.1038/s41593-022-01140-3
![Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson’s disease pathogenesis](https://media.springernature.com/w138/springer-static/cover/journal/401/137/1.jpg)
Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson’s disease pathogenesis
Acta Neuropathologica
·
17 Sep 2018
·
doi:10.1007/s00401-018-1907-y
All
2024
![The diversity of<i>SNCA</i>transcripts in neurons, and its impact on antisense oligonucleotide therapeutics](https://www.biorxiv.org/sites/default/files/biorxiv_logo_homepage.png)
The diversity ofSNCAtranscripts in neurons, and its impact on antisense oligonucleotide therapeutics
Cold Spring Harbor Laboratory
·
31 May 2024
·
doi:10.1101/2024.05.30.596437
![GLP1 receptor agonism ameliorates Parkinson’s disease through modulation of neuronal insulin signalling and glial suppression](https://www.biorxiv.org/sites/default/files/biorxiv_logo_homepage.png)
GLP1 receptor agonism ameliorates Parkinson’s disease through modulation of neuronal insulin signalling and glial suppression
Cold Spring Harbor Laboratory
·
28 Feb 2024
·
doi:10.1101/2024.02.28.582460
![Alpha-synuclein aggregates trigger anti-viral immune pathways and RNA editing in human astrocytes](https://www.biorxiv.org/sites/default/files/biorxiv_logo_homepage.png)
Alpha-synuclein aggregates trigger anti-viral immune pathways and RNA editing in human astrocytes
Cold Spring Harbor Laboratory
·
28 Feb 2024
·
doi:10.1101/2024.02.26.582055
2023
Prediction of mechanistic subtypes of Parkinson’s using patient-derived stem cell models
Nature Machine Intelligence
·
10 Aug 2023
·
doi:10.1038/s42256-023-00702-9
2022
Protein aggregation and calcium dysregulation are hallmarks of familial Parkinson’s disease in midbrain dopaminergic neurons
npj Parkinson's Disease
·
24 Nov 2022
·
doi:10.1038/s41531-022-00423-7
Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity
Nature Neuroscience
·
30 Aug 2022
·
doi:10.1038/s41593-022-01140-3
![The Impact of Type 2 Diabetes in Parkinson's Disease](https://movementdisorders.onlinelibrary.wiley.com/cms/asset/694968c7-fed7-49a1-bf22-c9d5c347547a/mds.v37.8.cover.jpg)
The Impact of Type 2 Diabetes in Parkinson's Disease
Movement Disorders
·
14 Jun 2022
·
doi:10.1002/mds.29122
2020
Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation
Cell Death & Differentiation
·
27 Apr 2020
·
doi:10.1038/s41418-020-0542-z
Beta amyloid aggregates induce sensitised TLR4 signalling causing long-term potentiation deficit and rat neuronal cell death
Communications Biology
·
18 Feb 2020
·
doi:10.1038/s42003-020-0792-9
![Tracking Oligomerization of Alpha-Synuclein Demonstrates Pivotal Role of Mitochondria in Seeding](https://www.cell.com/cms/asset/08f4efb2-16ac-4b43-820a-ba45eb40b10f/cov200h.gif)
Tracking Oligomerization of Alpha-Synuclein Demonstrates Pivotal Role of Mitochondria in Seeding
Biophysical Journal
·
01 Feb 2020
·
doi:10.1016/j.bpj.2019.11.1289
2018
![Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson’s disease pathogenesis](https://media.springernature.com/w138/springer-static/cover/journal/401/137/1.jpg)
Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson’s disease pathogenesis
Acta Neuropathologica
·
17 Sep 2018
·
doi:10.1007/s00401-018-1907-y
![Nanoscopic Characterisation of Individual Endogenous Protein Aggregates in Human Neuronal Cells](https://chemistry-europe.onlinelibrary.wiley.com/cms/asset/5397eb37-34f9-43e6-86f2-0e8509247448/cbic.v19.19.cover.jpg)
Nanoscopic Characterisation of Individual Endogenous Protein Aggregates in Human Neuronal Cells
ChemBioChem
·
11 Sep 2018
·
doi:10.1002/cbic.201800209
![Crucial role of protein oligomerization in the pathogenesis of Alzheimer's and Parkinson's diseases](https://febs.onlinelibrary.wiley.com/cms/asset/678ff62a-d26a-4566-ba0c-99d67daa3f07/febs.2018.285.issue-19.cover.jpg)
Crucial role of protein oligomerization in the pathogenesis of Alzheimer's and Parkinson's diseases
The FEBS Journal
·
21 Aug 2018
·
doi:10.1111/febs.14587
α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease
Nature Communications
·
12 Jun 2018
·
doi:10.1038/s41467-018-04422-2
![Overproduction of reactive oxygen species is the primary pathological event related to neuronal cell death in iPSC derived neurons from patients with familial Parkinson's disease](https://ars.els-cdn.com/content/image/S08915849.gif)
Overproduction of reactive oxygen species is the primary pathological event related to neuronal cell death in iPSC derived neurons from patients with familial Parkinson's disease
Free Radical Biology and Medicine
·
01 May 2018
·
doi:10.1016/j.freeradbiomed.2018.04.532
![Alpha-synuclein induces ferroptosis through generation of lipid peroxidation and calcium deregulation](https://ars.els-cdn.com/content/image/S08915849.gif)
Alpha-synuclein induces ferroptosis through generation of lipid peroxidation and calcium deregulation
Free Radical Biology and Medicine
·
01 May 2018
·
doi:10.1016/j.freeradbiomed.2018.04.137
2017
Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species
BMC Biology
·
03 Jul 2017
·
doi:10.1186/s12915-017-0390-6
![Progressive Motor Neuron Pathology and the Role of Astrocytes in a Human Stem Cell Model of VCP-Related ALS](https://ars.els-cdn.com/content/image/1-s2.0-S2211124716X0023X-cov200h.gif)
Progressive Motor Neuron Pathology and the Role of Astrocytes in a Human Stem Cell Model of VCP-Related ALS
Cell Reports
·
01 May 2017
·
doi:10.1016/j.celrep.2017.05.024
![Direct Modulation of the Mitochondrial Permeability Transition Pore by Oligomeric Alpha-Synuclein Causes Toxicity in PD](https://www.cell.com/cms/asset/780de9ac-5681-4006-8c8b-d1792a98befe/cov200h.gif)
Direct Modulation of the Mitochondrial Permeability Transition Pore by Oligomeric Alpha-Synuclein Causes Toxicity in PD
Biophysical Journal
·
01 Feb 2017
·
doi:10.1016/j.bpj.2016.11.2351
2016
![Arachidonic acid mediates the formation of abundant alpha-helical multimers of alpha-synuclein](https://www.openacessjournal.com/assets/membership/2020041548Scien.jpg)
Arachidonic acid mediates the formation of abundant alpha-helical multimers of alpha-synuclein
Scientific Reports
·
27 Sep 2016
·
doi:10.1038/srep33928
![Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading](https://www.pnas.org/cms/asset/7a19cdf3-0b97-472a-b6e7-621e52e95bc8/pnas.2016.113.issue-7.largecover.png)
Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading
Proceedings of the National Academy of Sciences
·
16 Feb 2016
·
doi:10.1073/pnas.1524128113
![Strain Dependent Effects of Alpha-Synuclein Mutations on Mitochondrial Dysfunction](https://ars.els-cdn.com/content/image/1-s2.0-S0006349515X00051-cov200h.gif)
Strain Dependent Effects of Alpha-Synuclein Mutations on Mitochondrial Dysfunction
Biophysical Journal
·
01 Feb 2016
·
doi:10.1016/j.bpj.2015.11.2522
2015
![A simple assessment model to quantifying the dynamic hippocampal neurogenic process in the adult mammalian brain](https://onlinelibrary.wiley.com/cms/asset/cfbcf59f-2b3e-4875-a431-b305a0113459/hipo.v26.4.cover.jpg)
A simple assessment model to quantifying the dynamic hippocampal neurogenic process in the adult mammalian brain
Hippocampus
·
03 Nov 2015
·
doi:10.1002/hipo.22541
![The Fabry disease-associated lipid Lyso-Gb3 enhances voltage-gated calcium currents in sensory neurons and causes pain](https://ars.els-cdn.com/content/image/1-s2.0-S0304394015X00073-cov200h.gif)
The Fabry disease-associated lipid Lyso-Gb3 enhances voltage-gated calcium currents in sensory neurons and causes pain
Neuroscience Letters
·
01 May 2015
·
doi:10.1016/j.neulet.2015.01.084
2014
![Dopaminergic manipulations and its effects on neurogenesis and motor function in a transgenic mouse model of Huntington's disease](https://ars.els-cdn.com/content/image/1-s2.0-S0969996114X00033-cov200h.gif)
Dopaminergic manipulations and its effects on neurogenesis and motor function in a transgenic mouse model of Huntington's disease
Neurobiology of Disease
·
01 Jun 2014
·
doi:10.1016/j.nbd.2014.02.004
2009
![A Functional Role for Adult Hippocampal Neurogenesis in Spatial Pattern Separation](https://www.science.org/cms/asset/9424fe86-4eae-4d2f-aeee-c09b534d1b9a/science.2009.325.issue-5937.largecover.jpg)
A Functional Role for Adult Hippocampal Neurogenesis in Spatial Pattern Separation
Science
·
10 Jul 2009
·
doi:10.1126/science.1173215
2008
![Vascular endothelial growth factor (VEGF) signaling regulates hippocampal neurons by elevation of intracellular calcium and activation of calcium/calmodulin protein kinase II and mammalian target of rapamycin](https://ars.els-cdn.com/content/image/1-s2.0-S0898656807X01785-cov200h.gif)
Vascular endothelial growth factor (VEGF) signaling regulates hippocampal neurons by elevation of intracellular calcium and activation of calcium/calmodulin protein kinase II and mammalian target of rapamycin
Cellular Signalling
·
01 Apr 2008
·
doi:10.1016/j.cellsig.2007.12.009