Publications
We post our published works on this page. You can also find additional information about our research activities via the links below.
Selected
Prediction of mechanistic subtypes of Parkinson’s using patient-derived stem cell models
Karishma D’Sa, James R. Evans, Gurvir S. Virdi, Giulia Vecchi, Alexander Adam, ..., Craig Leighton, Mathew H. Horrocks, Dilan Athauda, Minee L. Choi, Sonia Gandhi
Nature Machine Intelligence
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10 Aug 2023
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doi:10.1038/s42256-023-00702-9
Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity
Minee L. Choi, Alexandre Chappard, Bhanu P. Singh, Catherine Maclachlan, Margarida Rodrigues, ..., Lucy Collinson, David Klenerman, Andrey Y. Abramov, Mathew H. Horrocks, Sonia Gandhi
Nature Neuroscience
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30 Aug 2022
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doi:10.1038/s41593-022-01140-3
Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson’s disease pathogenesis
Craig D. Hughes, Minee L. Choi, Mina Ryten, Lee Hopkins, Anna Drews, ..., Margarida Rodrigues, Sarah A. Gagliano, Sonia Gandhi, Clare Bryant, David Klenerman
Acta Neuropathologica
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17 Sep 2018
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doi:10.1007/s00401-018-1907-y
All
AI
hiPSC
Parkinson's
Alzheimer's
Mitochondria
Protein aggregation
Cell death
Ferroptosis
Inflammation
Synucleinopathy
Fabry disease
Huntington's
Hippocampus
Learning Memory
Neurogenesis
1st Author
Corresponding Author
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2024
The diversity ofSNCAtranscripts in neurons, and its impact on antisense oligonucleotide therapeutics
James R. Evans, Emil K. Gustavsson, Ivan Doykov, David Murphy, Gurvir S. Virdi, ..., Michele Vendruscolo, Kevin Mills, Wendy Heywood, Mina Ryten, Sonia Gandhi
Cold Spring Harbor Laboratory
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31 May 2024
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doi:10.1101/2024.05.30.596437
GLP1 receptor agonism ameliorates Parkinson’s disease through modulation of neuronal insulin signalling and glial suppression
Dilan Athauda, James R Evans, Laura Mahoney-Sanchez, Gurvir S Virdi, Patricia Lopez-Garcia, ..., Mina Ryten, Mathew H. Horrocks, Nigel Greig, Thomas Foltynie, Sonia Gandhi
Cold Spring Harbor Laboratory
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28 Feb 2024
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doi:10.1101/2024.02.28.582460
Astrocytic RNA editing regulates the host immune response to alpha-synuclein
Karishma D’Sa, Minee L. Choi, Aaron Z. Wagen, Núria Setó-Salvia, Olga Kopach, ..., Rickie Patani, Clare Bryant, David A. Klenerman, Sonia Gandhi, Mina Ryten
Cold Spring Harbor Laboratory
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28 Feb 2024
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doi:10.1101/2024.02.26.582055
2023
Prediction of mechanistic subtypes of Parkinson’s using patient-derived stem cell models
Karishma D’Sa, James R. Evans, Gurvir S. Virdi, Giulia Vecchi, Alexander Adam, ..., Craig Leighton, Mathew H. Horrocks, Dilan Athauda, Minee L. Choi, Sonia Gandhi
Nature Machine Intelligence
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10 Aug 2023
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doi:10.1038/s42256-023-00702-9
2022
Protein aggregation and calcium dysregulation are hallmarks of familial Parkinson’s disease in midbrain dopaminergic neurons
Gurvir S. Virdi, Minee L. Choi, James R. Evans, Zhi Yao, Dilan Athauda, ..., Tilo Kunath, Mathew H. Horrocks, Andrey Y. Abramov, Rickie Patani, Sonia Gandhi
npj Parkinson's Disease
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24 Nov 2022
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doi:10.1038/s41531-022-00423-7
Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity
Minee L. Choi, Alexandre Chappard, Bhanu P. Singh, Catherine Maclachlan, Margarida Rodrigues, ..., Lucy Collinson, David Klenerman, Andrey Y. Abramov, Mathew H. Horrocks, Sonia Gandhi
Nature Neuroscience
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30 Aug 2022
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doi:10.1038/s41593-022-01140-3
The Impact of Type 2 Diabetes in Parkinson's Disease
Dilan Athauda, James Evans, Anna Wernick, Gurvir Virdi, Minee L. Choi, ..., Khalida Ismail, Huw Morris, Donald Grosset, Thomas Foltynie, Sonia Gandhi
Movement Disorders
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14 Jun 2022
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doi:10.1002/mds.29122
2020
Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation
Plamena R. Angelova, Minee L. Choi, Alexey V. Berezhnov, Mathew H. Horrocks, Craig D. Hughes, ..., Sergiy Sylantyev, Evgeny V. Pavlov, David Klenerman, Andrey Y. Abramov, Sonia Gandhi
Cell Death & Differentiation
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27 Apr 2020
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doi:10.1038/s41418-020-0542-z
Beta amyloid aggregates induce sensitised TLR4 signalling causing long-term potentiation deficit and rat neuronal cell death
Craig Hughes, Minee L. Choi, Jee-Hyun Yi, Seung-Chan Kim, Anna Drews, Peter St. George-Hyslop, Clare Bryant, Sonia Gandhi, Kwangwook Cho, David Klenerman
Communications Biology
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18 Feb 2020
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doi:10.1038/s42003-020-0792-9
Tracking Oligomerization of Alpha-Synuclein Demonstrates Pivotal Role of Mitochondria in Seeding
Minee L. Choi, Mathew H. Horrocks, Margarida Rodrigues, Suman De, Laura Tosatto, Weilia Zhang, Gurvir Virdi, David Klenerman, Andrey Y. Abramov, Sonia Gandhi
Biophysical Journal
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01 Feb 2020
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doi:10.1016/j.bpj.2019.11.1289
2018
Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson’s disease pathogenesis
Craig D. Hughes, Minee L. Choi, Mina Ryten, Lee Hopkins, Anna Drews, ..., Margarida Rodrigues, Sarah A. Gagliano, Sonia Gandhi, Clare Bryant, David Klenerman
Acta Neuropathologica
·
17 Sep 2018
·
doi:10.1007/s00401-018-1907-y
Nanoscopic Characterisation of Individual Endogenous Protein Aggregates in Human Neuronal Cells
Daniel R. Whiten, Yukun Zuo, Laura Calo, Minee‐Liane Choi, Suman De, ..., Christopher M. Dobson, Sonia Gandhi, Maria‐Grazia Spillantini, David Klenerman, Mathew H. Horrocks
ChemBioChem
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11 Sep 2018
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doi:10.1002/cbic.201800209
Crucial role of protein oligomerization in the pathogenesis of Alzheimer's and Parkinson's diseases
Minee L. Choi, Sonia Gandhi
The FEBS Journal
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21 Aug 2018
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doi:10.1111/febs.14587
α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease
Marthe H. R. Ludtmann, Plamena R. Angelova, Mathew H. Horrocks, Minee L. Choi, Margarida Rodrigues, ..., Morana Jaganjac, Evgeny V. Pavlov, David Klenerman, Andrey Y. Abramov, Sonia Gandhi
Nature Communications
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12 Jun 2018
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doi:10.1038/s41467-018-04422-2
Overproduction of reactive oxygen species is the primary pathological event related to neuronal cell death in iPSC derived neurons from patients with familial Parkinson's disease
Minee L Choi, Ruta Meleckyte, Daniel Little, Andrey Y Abramov, Rickie Patani, Sonia Gandhi
Free Radical Biology and Medicine
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01 May 2018
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doi:10.1016/j.freeradbiomed.2018.04.532
Alpha-synuclein induces ferroptosis through generation of lipid peroxidation and calcium deregulation
Plamena R. Angelova, Minee-Liane Choi, Mathew H. Horrocks, David Klenerman, Sonia Gandhi, Andrey Y. Abramov
Free Radical Biology and Medicine
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01 May 2018
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doi:10.1016/j.freeradbiomed.2018.04.137
2017
Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species
Marija Iljina, Liu Hong, Mathew H. Horrocks, Marthe H. Ludtmann, Minee L. Choi, ..., Michele Vendruscolo, Tuomas P. J. Knowles, Christopher M. Dobson, Erwin De Genst, David Klenerman
BMC Biology
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03 Jul 2017
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doi:10.1186/s12915-017-0390-6
Progressive Motor Neuron Pathology and the Role of Astrocytes in a Human Stem Cell Model of VCP-Related ALS
Claire E. Hall, Zhi Yao, Minee Choi, Giulia E. Tyzack, Andrea Serio, ..., Christopher R. Sibley, Andras Lakatos, Jernej Ule, Sonia Gandhi, Rickie Patani
Cell Reports
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01 May 2017
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doi:10.1016/j.celrep.2017.05.024
Direct Modulation of the Mitochondrial Permeability Transition Pore by Oligomeric Alpha-Synuclein Causes Toxicity in PD
Marthe Ludtmann, Plamena Angelova, Minee-Liane Choi, Mathew Horrocks, Artyom Baev, ..., Paul Gissen, Evgeny Pavlov, David Klenerman, Andrey Abramov, Sonia Gandhi
Biophysical Journal
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01 Feb 2017
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doi:10.1016/j.bpj.2016.11.2351
2016
Arachidonic acid mediates the formation of abundant alpha-helical multimers of alpha-synuclein
Marija Iljina, Laura Tosatto, Minee L. Choi, Jason C. Sang, Yu Ye, Craig D. Hughes, Clare E. Bryant, Sonia Gandhi, David Klenerman
Scientific Reports
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27 Sep 2016
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doi:10.1038/srep33928
Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading
Marija Iljina, Gonzalo A. Garcia, Mathew H. Horrocks, Laura Tosatto, Minee L. Choi, ..., Nicholas W. Wood, Nunilo Cremades, Christopher M. Dobson, Tuomas P. J. Knowles, David Klenerman
Proceedings of the National Academy of Sciences
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16 Feb 2016
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doi:10.1073/pnas.1524128113
Strain Dependent Effects of Alpha-Synuclein Mutations on Mitochondrial Dysfunction
Minee L. Choi, Zhi Yao, Laura Tosatto, David Klenerman, Andrey Y. Abramov, Sonia Gandhi
Biophysical Journal
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01 Feb 2016
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doi:10.1016/j.bpj.2015.11.2522
2015
A simple assessment model to quantifying the dynamic hippocampal neurogenic process in the adult mammalian brain
Minee L. Choi, Faye Begeti, Roger A. Barker, Namho Kim
Hippocampus
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03 Nov 2015
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doi:10.1002/hipo.22541
The Fabry disease-associated lipid Lyso-Gb3 enhances voltage-gated calcium currents in sensory neurons and causes pain
L. Choi, J. Vernon, O. Kopach, M.S. Minett, K. Mills, P.T. Clayton, T. Meert, J.N. Wood
Neuroscience Letters
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01 May 2015
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doi:10.1016/j.neulet.2015.01.084
2014
Dopaminergic manipulations and its effects on neurogenesis and motor function in a transgenic mouse model of Huntington's disease
M.L. Choi, F. Begeti, J.H. Oh, S.Y. Lee, G.C. O'Keeffe, C.D. Clelland, P. Tyers, Z.H. Cho, Y.B. Kim, R.A. Barker
Neurobiology of Disease
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01 Jun 2014
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doi:10.1016/j.nbd.2014.02.004
2009
A Functional Role for Adult Hippocampal Neurogenesis in Spatial Pattern Separation
C. D. Clelland, M. Choi, C. Romberg, G. D. Clemenson, A. Fragniere, ..., S. Jessberger, L. M. Saksida, R. A. Barker, F. H. Gage, T. J. Bussey
Science
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10 Jul 2009
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doi:10.1126/science.1173215
2008
Vascular endothelial growth factor (VEGF) signaling regulates hippocampal neurons by elevation of intracellular calcium and activation of calcium/calmodulin protein kinase II and mammalian target of rapamycin
Byung Woo Kim, Minee Choi, Yong-Seok Kim, Hyungju Park, Hye-Ryeon Lee, ..., June-Seek Choi, Sunoh Kim, Hyewon Rhim, Bong-Kiun Kaang, Hyeon Son
Cellular Signalling
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01 Apr 2008
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doi:10.1016/j.cellsig.2007.12.009