BRAIN RePAIR & ORGANØID 1NTEL by Minee Choi

Publications

We post our published works on this page. You can also find additional information about our research activities via the links below.

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Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity
Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity
Minee L. Choi, Alexandre Chappard, Bhanu P. Singh, Catherine Maclachlan, Margarida Rodrigues, ..., Lucy Collinson, David Klenerman, Andrey Y. Abramov, Mathew H. Horrocks, Sonia Gandhi
Nature Neuroscience   ·   30 Aug 2022   ·   doi:10.1038/s41593-022-01140-3
Synucleinopathy Protein aggregation Parkinson's Mitochondria hiPSC 1st Author
Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson’s disease pathogenesis
Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson’s disease pathogenesis
Craig D. Hughes, Minee L. Choi, Mina Ryten, Lee Hopkins, Anna Drews, ..., Margarida Rodrigues, Sarah A. Gagliano, Sonia Gandhi, Clare Bryant, David Klenerman
Acta Neuropathologica   ·   17 Sep 2018   ·   doi:10.1007/s00401-018-1907-y
Parkinson's Alpha-Synuclein 1st Author

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AI hiPSC Parkinson's Alzheimer's Mitochondria Protein aggregation Cell death Ferroptosis Inflammation Synucleinopathy Fabry disease Huntington's Hippocampus Learning Memory Neurogenesis 1st Author Corresponding Author
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2024

2023

2022

Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity
Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity
Minee L. Choi, Alexandre Chappard, Bhanu P. Singh, Catherine Maclachlan, Margarida Rodrigues, ..., Lucy Collinson, David Klenerman, Andrey Y. Abramov, Mathew H. Horrocks, Sonia Gandhi
Nature Neuroscience   ·   30 Aug 2022   ·   doi:10.1038/s41593-022-01140-3
Synucleinopathy Protein aggregation Parkinson's Mitochondria hiPSC 1st Author

2020

Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation
Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation
Plamena R. Angelova, Minee L. Choi, Alexey V. Berezhnov, Mathew H. Horrocks, Craig D. Hughes, ..., Sergiy Sylantyev, Evgeny V. Pavlov, David Klenerman, Andrey Y. Abramov, Sonia Gandhi
Cell Death & Differentiation   ·   27 Apr 2020   ·   doi:10.1038/s41418-020-0542-z
Synucleinopathy Protein aggregation Parkinson's Ferroptosis 1st Author
Beta amyloid aggregates induce sensitised TLR4 signalling causing long-term potentiation deficit and rat neuronal cell death
Beta amyloid aggregates induce sensitised TLR4 signalling causing long-term potentiation deficit and rat neuronal cell death
Craig Hughes, Minee L. Choi, Jee-Hyun Yi, Seung-Chan Kim, Anna Drews, Peter St. George-Hyslop, Clare Bryant, Sonia Gandhi, Kwangwook Cho, David Klenerman
Communications Biology   ·   18 Feb 2020   ·   doi:10.1038/s42003-020-0792-9
Inflammation Alzheimer's Protein aggregation hiPSC
Tracking Oligomerization of Alpha-Synuclein Demonstrates Pivotal Role of Mitochondria in Seeding
Tracking Oligomerization of Alpha-Synuclein Demonstrates Pivotal Role of Mitochondria in Seeding
Minee L. Choi, Mathew H. Horrocks, Margarida Rodrigues, Suman De, Laura Tosatto, Weilia Zhang, Gurvir Virdi, David Klenerman, Andrey Y. Abramov, Sonia Gandhi
Biophysical Journal   ·   01 Feb 2020   ·   doi:10.1016/j.bpj.2019.11.1289
Alpha-Synuclein Mitochondria 1st Author

2018

Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson’s disease pathogenesis
Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson’s disease pathogenesis
Craig D. Hughes, Minee L. Choi, Mina Ryten, Lee Hopkins, Anna Drews, ..., Margarida Rodrigues, Sarah A. Gagliano, Sonia Gandhi, Clare Bryant, David Klenerman
Acta Neuropathologica   ·   17 Sep 2018   ·   doi:10.1007/s00401-018-1907-y
Parkinson's Alpha-Synuclein 1st Author
Nanoscopic Characterisation of Individual Endogenous Protein Aggregates in Human Neuronal Cells
Nanoscopic Characterisation of Individual Endogenous Protein Aggregates in Human Neuronal Cells
Daniel R. Whiten, Yukun Zuo, Laura Calo, Minee‐Liane Choi, Suman De, ..., Christopher M. Dobson, Sonia Gandhi, Maria‐Grazia Spillantini, David Klenerman, Mathew H. Horrocks
ChemBioChem   ·   11 Sep 2018   ·   doi:10.1002/cbic.201800209
Protein aggregation hiPSC
α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease
α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease
Marthe H. R. Ludtmann, Plamena R. Angelova, Mathew H. Horrocks, Minee L. Choi, Margarida Rodrigues, ..., Morana Jaganjac, Evgeny V. Pavlov, David Klenerman, Andrey Y. Abramov, Sonia Gandhi
Nature Communications   ·   12 Jun 2018   ·   doi:10.1038/s41467-018-04422-2
Parkinson's Alpha-Synuclein hiPSC
Alpha-synuclein induces ferroptosis through generation of lipid peroxidation and calcium deregulation
Alpha-synuclein induces ferroptosis through generation of lipid peroxidation and calcium deregulation
Plamena R. Angelova, Minee-Liane Choi, Mathew H. Horrocks, David Klenerman, Sonia Gandhi, Andrey Y. Abramov
Free Radical Biology and Medicine   ·   01 May 2018   ·   doi:10.1016/j.freeradbiomed.2018.04.137
Alpha-Synuclein Ferroptosis

2017

Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species
Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species
Marija Iljina, Liu Hong, Mathew H. Horrocks, Marthe H. Ludtmann, Minee L. Choi, ..., Michele Vendruscolo, Tuomas P. J. Knowles, Christopher M. Dobson, Erwin De Genst, David Klenerman
BMC Biology   ·   03 Jul 2017   ·   doi:10.1186/s12915-017-0390-6
Alpha-Synuclein
Direct Modulation of the Mitochondrial Permeability Transition Pore by Oligomeric Alpha-Synuclein Causes Toxicity in PD
Direct Modulation of the Mitochondrial Permeability Transition Pore by Oligomeric Alpha-Synuclein Causes Toxicity in PD
Marthe Ludtmann, Plamena Angelova, Minee-Liane Choi, Mathew Horrocks, Artyom Baev, ..., Paul Gissen, Evgeny Pavlov, David Klenerman, Andrey Abramov, Sonia Gandhi
Biophysical Journal   ·   01 Feb 2017   ·   doi:10.1016/j.bpj.2016.11.2351
Parkinson's Mitochondria hiPSC

2016

Arachidonic acid mediates the formation of abundant alpha-helical multimers of alpha-synuclein
Arachidonic acid mediates the formation of abundant alpha-helical multimers of alpha-synuclein
Marija Iljina, Laura Tosatto, Minee L. Choi, Jason C. Sang, Yu Ye, Craig D. Hughes, Clare E. Bryant, Sonia Gandhi, David Klenerman
Scientific Reports   ·   27 Sep 2016   ·   doi:10.1038/srep33928
Parkinson's Alpha-Synuclein
Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading
Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading
Marija Iljina, Gonzalo A. Garcia, Mathew H. Horrocks, Laura Tosatto, Minee L. Choi, ..., Nicholas W. Wood, Nunilo Cremades, Christopher M. Dobson, Tuomas P. J. Knowles, David Klenerman
Proceedings of the National Academy of Sciences   ·   16 Feb 2016   ·   doi:10.1073/pnas.1524128113
Parkinson's Alpha-Synuclein
Strain Dependent Effects of Alpha-Synuclein Mutations on Mitochondrial Dysfunction
Strain Dependent Effects of Alpha-Synuclein Mutations on Mitochondrial Dysfunction
Minee L. Choi, Zhi Yao, Laura Tosatto, David Klenerman, Andrey Y. Abramov, Sonia Gandhi
Biophysical Journal   ·   01 Feb 2016   ·   doi:10.1016/j.bpj.2015.11.2522
Parkinson's Alpha-Synuclein Mitochondria 1st Author

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